We are recruiting a Scientist to drive innovation in cell engineering and phenotypic screening models within Roche’s Therapeutic Modalities. You will design and optimise disease-relevant cellular models and collaborate across therapeutic areas. At Roche, you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.
Tasks
- Independently design, engineer, validate, and optimize disease-relevant cellular models at scale to enable phenotypic screening and small molecule drug discovery.
- Apply diverse cell engineering approaches, including CRISPR/Cas technologies, vector design, reporter systems, and stable cell line generation, to build robust assay systems.
- Translate complex cellular models into scalable, reproducible, screening-compatible workflows for high-content imaging and phenotypic screening.
- Partner actively across therapeutic areas, automation, data analysis, and chemistry teams to interpret results, present data, and support project decisions.
- Actively cultivate an inclusive, collaborative, and curious team environment focused on pushing scientific boundaries.
Requirements
- A PhD in cell biology, molecular biology, or a closely related scientific discipline.
- Postdoctoral or industry research experience is a plus but not required.
- Strong hands-on experience in advanced cell culture techniques, including iPSC differentiation and larger-scale cell culture.
- Extensive practical experience in cell engineering, particularly CRISPR/Cas-based genome editing, stable cell line generation, clonal isolation, genotyping, and validation using Next-Generation Sequencing (NGS).
- Solid experience with cloning, transfection, viral transduction, nucleofection, as well as plasmid, vector, and genetic element design (promoters, reporters, tags).
- Solid exposure to high-content imaging, assay development, automated cell culture, or high-throughput screening using small molecules or genetic tools.
- Expertise in high-content data analysis, image processing pipelines, or multiparametric data evaluation is a plus.
- Resourceful, flexible problem-solving skills with a highly collaborative approach and strong communication skills in English.
- This position is 100% lab-based.
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Über uns
Das Team
You will join Small Molecule Research Discovery within Therapeutic Modalities, working in a highly engaged, cross-functional team bridging cell biology, automation, and multiple therapeutic areas.